高木繁夫氏論文2本忘備録
Prostaglandins. 1977 Oct;14(4):791-8.
doi: 10.1016/0090-6980(77)90208-8.
Termination of early pregnancy by ONO-802 (16,16-dimethyl-trans-delta2-PGE1 methyl ester)
S Takagi, H Sakata, T Yoshida, S Nakazawa, K T Fujii, Y Tominaga, Y Iwasa, T Ninagawa, T Hiroshima, Y Tomida, K Itoh, R Matsukawa
• PMID: 594380
• DOI: 10.1016/0090-6980(77)90208-8
Abstract
ONO-802 was infused into the uterine cavity for the termination of early pregnancy in 45 healthy volunteers. Forty two (93%) of the 45 cases had complete abortions and two had incomplete abortions. Nine (20%) of the 45 volunteers complained of nausea, 7 (16%) vomited and 5 (11%) complained of abdominal pain. Neither diarrhea nor weakness was observed. These results suggest that ONO-802 is more acceptable for the termination of early pregnancy than is PGF2alpha.
健康なボランティア45名を対象に、早期妊娠の終了を目的としてONO-802を子宮腔内へ注入した。45例中42例（93％）が完全流産、2例が不完全流産であった。45例のボランティアのうち9例（20％）が吐き気を訴え、7例（16％）が嘔吐し、5例（11％）が腹痛を訴えた。下痢や衰弱は観察されなかった。これらの結果は、ONO-802がPGF2αよりも早期妊娠の終了に受け入れられることを示唆している。
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• Prostaglandin regulation of the content of sex hormone receptors in human decidual tissue.
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MeSH terms
• Abortion, Induced*, Estradiol / blood, Female, Humans, Pregnancy, Progesterone / blood, Prostaglandins E / adverse effects, Prostaglandins E / therapeutic use*, Time Factors
Prostaglandins
. 1978 May;15(5):913-9. doi: 10.1016/0090-6980(78)90159-4.
Termination of early pregnancy by ONO-802 suppositories (16,16-dimethyl-trans-delta2-PGE1 methyl ester)
S Takagi, H Sakata, T Yoshida, K Den, T K Fujii, H Amemiya, M Tomita
PMID: 704915 DOI: 10.1016/0090-6980(78)90159-4
Abstract
ONO-802 was used in the form of vaginal suppositories for the termination of early pregnancy in 63 healthy volunteers. Fifty-four (86%) of the 63 cases had complete abortions and remaining 9 (14%) had incomplete abortions. One (1.6%) of the 63 cases complained of nausea and vomiting, and 3 (4.8%) complained of headaches. No other side effects were observed. These results suggest that ONO-802 is acceptable in the form of vaginal suppositories for the termination of early pregnancy.
ONO-802は、63人の健康なボランティアに初期の妊娠を終了させるために膣座薬の形で使用されました。63例中54例（86％）が完全流産、残りの9例（14％）は不完全流産でした。63例中1例（1.6％）に悪心・嘔吐、3例（4.8％）に頭痛を訴えた。その他の副作用は認められませんでした。以上の結果より、ONO-802は膣座薬の形で早期妊娠の終了に使用できることが示唆された。PIP: 63 pregnant women (aged 20-35 years) with a parity range from 0-3 (average 1.6+-.8) were treated in vaginal suppository form with ONO-802 at either .5 or 1 mg. Pregnancy-stage range was from 11-66 days beyond last expected menstrual period. Patients were instructed to insert 1 suppository every 3 hours for a maximum of 5 applications. Estradiol and progesterone levels were assayed from venous blood samples before (control) administration and 3, 6, and 24 hours postadministration. No changes were present at onset of contractions, but all fractions decreased by 48 hours postadministration. 63/63 responded with hemorrhage. 54/63 (86%) had complete abortions (89% with 1 mg, 84% with .5 mg). 9/63 were incomplete (14%), but there was sufficient dilatation for subsequent uterine content removal. With the 1-mg dose, uterine contractions and hemorrhage occurred about 1.5 hours sooner. 1/63 (1.6%) complained of nausea and vomiting, and 3 (4.8%) complained of headache. No other side effects were observed.
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MeSH terms
Abortifacient Agents*
Abortifacient Agents, Nonsteroidal*
Adult
Female
Humans
Pregnancy
Prostaglandins E, Synthetic / administration & dosage
Prostaglandins E, Synthetic / adverse effects
Prostaglandins E, Synthetic / pharmacology*
Suppositories
Vagina
